Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.
PLoS One
; 9(2): e88776, 2014.
Article
en En
| MEDLINE
| ID: mdl-24586391
ABSTRACT
Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. However, TTP deficiency abrogated the effects of exogenous CO. While CO treatment prior to DSS administration in WT mice significantly reduced inflammatory cytokine levels and colitis, it failed to reduce the pro-inflammatory cytokine levels and colitis in TTP knockout (KO) mice. Our results demonstrate that TTP is a key factor mediating the anti-inflammatory action of CO in DSS-induced colitis.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Monóxido de Carbono
/
Sulfato de Dextran
/
Colitis
/
Tristetraprolina
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2014
Tipo del documento:
Article