A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
Ann Neurol
; 75(4): 602-7, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24591104
ABSTRACT
Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid ß (Aß) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aß levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aß production.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Péptidos beta-Amiloides
/
AMP Cíclico
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Memoria
/
Neuronas
Límite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Ann Neurol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia