Rectal site and suboptimal nodal yield predict systemic recurrence in resected colorectal carcinoma: a case-control study.
Int J Surg Pathol
; 22(6): 505-11, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24813440
ABSTRACT
We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design:
71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly greater odds of rectal site (odds ratio [OR] = 1.82), stage ≥ pT3 (OR = 2.11), suboptimal (<12) lymph node yield (OR = 4.6), stage ≥ pN1 (OR = 2.46), KRAS mutation (OR = 2.76), and extramural venous invasion (OR = 1.97). By multiple regression analysis, rectal site, stage ≥ pT3, suboptimal lymph node yield, and lymph node positivity independently predicted SR. Rectal cancers were more likely to have a suboptimal node yield than nonrectal cancers (relative risk = 1.6) among the entire cohort. We conclude that rectal cancers have greater risk of SR than colon cancers. A lower yield of lymph nodes in rectal cancer specimens may contribute to this.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Colorrectales
/
Adenocarcinoma
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Escisión del Ganglio Linfático
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Metástasis Linfática
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Recurrencia Local de Neoplasia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int J Surg Pathol
Asunto de la revista:
PATOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Irlanda