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Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973).
Rice, Kenneth D; Aay, Naing; Anand, Neel K; Blazey, Charles M; Bowles, Owen J; Bussenius, Joerg; Costanzo, Simona; Curtis, Jeffry K; Defina, Steven C; Dubenko, Larisa; Engst, Stefan; Joshi, Anagha A; Kennedy, Abigail R; Kim, Angie I; Koltun, Elena S; Lougheed, Julie C; Manalo, Jean-Claire L; Martini, Jean-Francois; Nuss, John M; Peto, Csaba J; Tsang, Tsze H; Yu, Peiwen; Johnston, Stuart.
Afiliación
  • Rice KD; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Aay N; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Anand NK; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Blazey CM; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Bowles OJ; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Bussenius J; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Costanzo S; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Curtis JK; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Defina SC; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Dubenko L; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Engst S; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Joshi AA; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Kennedy AR; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Kim AI; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Koltun ES; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Lougheed JC; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Manalo JC; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Martini JF; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Nuss JM; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Peto CJ; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Tsang TH; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Yu P; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
  • Johnston S; Exelixis Inc. , 210 East Grand Avenue, South San Francisco, California 94080, United States.
ACS Med Chem Lett ; 3(5): 416-21, 2012 May 10.
Article en En | MEDLINE | ID: mdl-24900486
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Texto completo: 1 Colección: 01-internacional Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos