Intraoperative Electron Radiotherapy (IOERT) as an Alternative to Standard Whole Breast Irradiation: Only for Low-Risk Subgroups?
Breast Care (Basel)
; 9(2): 102-6, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24944552
ABSTRACT
BACKGROUND:
Intraoperative radiotherapy during breast-conserving surgery is being studied as an alternative to 6 weeks of external beam radiotherapy (EBRT) for low-risk women; it can be delivered using electrons (intraoperative electron radiotherapy, IOERT) or 50-kV X-rays. MATERIALS ANDMETHODS:
We analyzed both single institutional and randomized studies involving single-fraction IOERT treatments. Rates for ipsilateral breast tumor recurrences, disease-specific survival, and overall survival were obtained.RESULTS:
IOERT had true 5-year recurrence rates of > 1.5% for ASTRO (American Society for Radiation Oncology) and ESTRO (European Society for Therapeutic Radiology and Oncology) suitable women, or for low-risk women as defined by the ELIOT trial. Women with ductal carcinoma in situ eligible for breast-conserving therapy, older women that currently receive no EBRT, and younger women with favorable biology are additional potential candidates.CONCLUSION:
ASTRO suitable and ESTRO good women for accelerated partial breast irradiation are low-risk groups. Higher-risk women with favorable biology might also be suitable candidates for IOERT, providing the tumor biology can be determined prior to surgery. For intraoperative radiotherapy using 50-kV X-rays, follow-up was too short to assess the effectiveness of the treatment.
Texto completo:
1
Colección:
01-internacional
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Risk_factors_studies
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Systematic_reviews
Idioma:
En
Revista:
Breast Care (Basel)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia