Plasma ß-amyloid 40 levels are positively associated with mortality risks in the elderly.
Alzheimers Dement
; 11(6): 672-80, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25022539
ABSTRACT
BACKGROUND:
We evaluated if plasma ß-amyloid (Aß) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study.METHODS:
Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aß and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators.RESULTS:
A relationship between high plasma Aß1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels.CONCLUSIONS:
Further investigations are needed to determine precisely the pathophysiological roles of plasma Aß1-40 and cystatin C and before envisioning any future clinical applications.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Fragmentos de Péptidos
/
Mortalidad
/
Péptidos beta-Amiloides
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia