Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth.
Biomed Mater
; 9(4): 045009, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-25029630
ABSTRACT
In this study, we report the production of amine functionalized nanodiamond. The amine functionalized nanodiamond forms a conformal monolayer on a negatively charged surface produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glioma hybrid cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating the potential of the coating for applications in the treatment of peripheral nerve injury.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Adhesión Celular
/
Neuritas
/
Proliferación Celular
/
Nanodiamantes
/
Aminas
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Biomed Mater
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido