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Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Hwang, Joo-Yeon; Sim, Xueling; Wu, Ying; Liang, Jun; Tabara, Yasuharu; Hu, Cheng; Hara, Kazuo; Tam, Claudia H T; Cai, Qiuyin; Zhao, Qi; Jee, Sunha; Takeuchi, Fumihiko; Go, Min Jin; Ong, Rick Twee Hee; Ohkubo, Takayoshi; Kim, Young Jin; Zhang, Rong; Yamauchi, Toshimasa; So, Wing Yee; Long, Jirong; Gu, Dongfeng; Lee, Nanette R; Kim, Soriul; Katsuya, Tomohiro; Oh, Ji Hee; Liu, Jianjun; Umemura, Satoshi; Kim, Yeon-Jung; Jiang, Feng; Maeda, Shiro; Chan, Juliana C N; Lu, Wei; Hixson, James E; Adair, Linda S; Jung, Keum Ji; Nabika, Toru; Bae, Jae-Bum; Lee, Mi Hee; Seielstad, Mark; Young, Terri L; Teo, Yik Ying; Kita, Yoshikuni; Takashima, Naoyuki; Osawa, Haruhiko; Lee, So-Hyun; Shin, Min-Ho; Shin, Dong Hoon; Choi, Bo Youl; Shi, Jiajun; Gao, Yu-Tang.
Afiliación
  • Hwang JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Sim X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
  • Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC.
  • Liang J; Department of Nutrition, Harvard School of Public Health, Boston, MA.
  • Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Hu C; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Hara K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan.
  • Tam CH; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
  • Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Zhao Q; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
  • Jee S; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
  • Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Go MJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Ong RT; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
  • Ohkubo T; Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
  • Kim YJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Zhang R; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • So WY; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
  • Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Gu D; State Key Laboratory of Cardiovascular Disease, Department of Epidemiology, National Center for Cardiovascular Diseases, Beijing, China Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China Peking Union Medical College, B
  • Lee NR; Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
  • Kim S; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
  • Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
  • Oh JH; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
  • Umemura S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
  • Kim YJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Jiang F; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Maeda S; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Chan JC; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
  • Lu W; Shanghai Municipal Center for Disease Control & Prevention, Shanghai, China.
  • Hixson JE; Human Genetics Center, The University of Texas School of Public Health, Houston, TX.
  • Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC.
  • Jung KJ; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
  • Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
  • Bae JB; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Lee MH; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Seielstad M; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA.
  • Young TL; Center for Human Genetics, Duke University Medical Center, Durham, NC.
  • Teo YY; Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore Department of Stati
  • Kita Y; Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
  • Takashima N; Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
  • Osawa H; Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
  • Lee SH; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
  • Shin DH; Department of Occupational and Environmental Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
  • Choi BY; Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
  • Shi J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
  • Gao YT; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetes ; 64(1): 291-8, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25187374
ABSTRACT
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Glucemia / Pueblo Asiatico / Estudio de Asociación del Genoma Completo Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Año: 2015 Tipo del documento: Article
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Glucemia / Pueblo Asiatico / Estudio de Asociación del Genoma Completo Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Año: 2015 Tipo del documento: Article