N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice.

Shi, Y; Dong, J W; Tang, L N; Kang, R X; Shi, J G; Zhang, J J

Shi, Y; Dong, J W; Tang, L N; Kang, R X; Shi, J G; Zhang, J J.

Afiliación

Shi Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Dong JW; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Tang LN; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Kang RX; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Shi JG; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Zhang JJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China. Electronic address: jjzhang@imm.ac.cn.

Pharmacol Biochem Behav ; 126: 146-51, 2014 Nov.

Article en En | MEDLINE | ID: mdl-25223978

Asunto(s)

Adenosina/análogos & derivados; Glutamato Descarboxilasa/metabolismo; Hipnóticos y Sedantes/farmacología; 4-Aminobutirato Transaminasa/metabolismo; Adenosina/antagonistas & inhibidores; Adenosina/farmacología; Animales; Corteza Cerebral/efectos de los fármacos; Corteza Cerebral/enzimología; Corteza Cerebral/metabolismo; Electroencefalografía; Activación Enzimática/efectos de los fármacos; Ácido Glutámico/metabolismo; Hipnóticos y Sedantes/antagonistas & inhibidores; Hipotálamo/efectos de los fármacos; Hipotálamo/enzimología; Hipotálamo/metabolismo; Masculino; Ratones; Semicarbacidas/farmacología; Fases del Sueño/efectos de los fármacos; Ácido gamma-Aminobutírico/metabolismo

Palabras clave

EEG; GABA; GAD; Sedativehypnotic; Semicarbazide hydrochloride

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Texto completo: 1 Colección: 01-internacional Asunto principal: Adenosina / Glutamato Descarboxilasa / Hipnóticos y Sedantes Límite: Animals Idioma: En Revista: Pharmacol Biochem Behav Año: 2014 Tipo del documento: Article

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