Adjuvant topical treatment with imiquimod 5% after excisional surgery for VIN 2/3.
Eur Rev Med Pharmacol Sci
; 18(19): 2949-52, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-25339491
ABSTRACT
OBJECTIVE:
Vulvar intraepithelial neoplasia (VIN) is a premalignant lesion of the vulva. The incidence of VIN is increasing. The surgery is currently the gold standard therapy for VIN, but Imiquimod could be a completion to surgery. The aim of this study is to compare the overall complete response, the recurrence rate and the risk factors for recurrence among two groups of patients women with high grade VIN underwent surgery and patients treated with surgery plus Imiquimod. PATIENTS ANDMETHODS:
80 patients with histologically diagnosed VIN 2/3 were enrolled in this prospective study. Our patients were divided into two groups 40 women underwent surgery (A) and 40 patients were treated with surgery plus Imiquimod (B). All women had a 5-year follow-up. Recurrence rate and complete response were evaluated. The following patients' characteristics were analyzed smoke, multifocal disease, multicentric disease, degree of the lesion.RESULTS:
In the group A recurrence rate was 44.8%, in the group B it was 48.4%. In both groups the presence of multifocal lesions (p = 0.02) and VIN 3 (p = 0.006) before treatment was associated with a higher risk of recurrence.CONCLUSIONS:
This study found that surgery remains the principal approach for VIN with regard to relapse and complete response since the treatment with Imiquimod associated with surgery didn't show a lower recurrence rate. Although the surgical treatments remain the best therapeutic option for VIN with regard to recurrence and overall complete response, the combined therapy seems to be an interesting modality, but further studies are needed.
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Colección:
01-internacional
Asunto principal:
Neoplasias de la Vulva
/
Carcinoma in Situ
/
Aminoquinolinas
/
Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia