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Effects of docosahexaenoic Acid on the endothelial function in patients with coronary artery disease.
Yagi, Shusuke; Aihara, Ken-ichi; Fukuda, Daiju; Takashima, Akira; Hara, Tomoya; Hotchi, Junko; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Iwase, Takashi; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Shimabukuro, Michio; Akaike, Masashi; Sata, Masataka.
Afiliación
  • Yagi S; Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan.
J Atheroscler Thromb ; 22(5): 447-54, 2015.
Article en En | MEDLINE | ID: mdl-25342567
ABSTRACT

AIM:

The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.

METHODS:

We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).

RESULTS:

A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (< 0.01) and age was a negative (P < 0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.

CONCLUSIONS:

The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Asunto principal: Enfermedad de la Arteria Coronaria / Endotelio Vascular / Ácidos Docosahexaenoicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Asunto principal: Enfermedad de la Arteria Coronaria / Endotelio Vascular / Ácidos Docosahexaenoicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón