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Liver resectability of advanced liver-limited colorectal liver metastases following mFOLFOX6 with bevacizumab (KSCC0802 Study).
Beppu, Toru; Emi, Yasunori; Tokunaga, Shoji; Oki, Eiji; Shirabe, Ken; Ueno, Shinichi; Kuramoto, Masafumi; Kabashima, Akira; Takahashi, Ikuo; Samura, Hironori; Eguchi, Susumu; Akagi, Yoshito; Natsugoe, Shoji; Ogata, Yutaka; Kakeji, Yoshihiro; Baba, Hideo; Maehara, Yoshihiko.
Afiliación
  • Beppu T; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Emi Y; Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
  • Tokunaga S; Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
  • Oki E; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Shirabe K; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Ueno S; Department of Clinical Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Kuramoto M; Department of Surgery, Kumamoto Social Insurance General Hospital, Kumamoto, Japan.
  • Kabashima A; Department of Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
  • Takahashi I; Department of Surgery, Matsuyama Red Cross Hospital, Ehime, Japan.
  • Samura H; Department of Surgery I, Ryukyu University, Okinawa, Japan.
  • Eguchi S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Akagi Y; Department of Surgery, Kurume University School of Medicine, Kurume, Japan.
  • Natsugoe S; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Ogata Y; Department of Surgery, Kurume University Medical Center, Kurume, Japan.
  • Kakeji Y; Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
  • Baba H; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  • Maehara Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan maehara@surg2.med.kyushu-u.ac.jp.
Anticancer Res ; 34(11): 6655-62, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25368271
ABSTRACT
BACKGROUND/

AIM:

The Kyushu Study group of Clinical Cancer (KSCC) conducted phase II trials (KSCC0802-UMIN000001308) concerning liver resectability after first-line treatment of advanced liver-limited colorectal metastases (CRLM) by a prospective, multi-center study. PATIENTS AND

METHODS:

Patients received 6 cycles of mFOLFOX6 with bevacizumab followed by evaluating liver resectability. The primary end-point was liver resection rate.

RESULTS:

The 40 patients enrolled from September 2008 to August 2010. The median number of administration cycles was 6 (range=1-7). The liver resectability cases were 16/40 (40.0 %) and the number of R0 cases was 10 patients (25.0%). An overall response rate was 30.0% (95% CI=15.2%-44.8%). Median progression-free and overall survival of all patients was 9.7 months and 33.0 months), respectively.

CONCLUSION:

mFOLFOX6 with bevacizumab regimen is safe and effective for advanced liver-limited CRLM and might lead to high liver resectability.
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Colección: 01-internacional Asunto principal: Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Hepatectomía / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Año: 2014 Tipo del documento: Article País de afiliación: Japón
Buscar en Google
Imprimir
XML
PubMed Links

Colección: 01-internacional Asunto principal: Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Hepatectomía / Neoplasias Hepáticas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Año: 2014 Tipo del documento: Article País de afiliación: Japón