Ascorbic acid PEG-2L is superior for early morning colonoscopies in colorectal cancer screening programs: a prospective non-randomized controlled trial.
Gastroenterol Hepatol
; 38(2): 62-70, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25458542
ABSTRACT
BACKGROUND:
The quality of colon cleansing and the tolerability of anterograde preparation are essential to the success of colorectal cancer screening.AIM:
To compare the tolerability and efficacy of low-volume preparations vs the standard regimen in individuals scheduled for an early morning colonoscopy. STUDY Participants in a population-based colorectal cancer screening program using the fecal immunochemical test who were scheduled for a colonoscopy from 0900 a.m. to 1020 a.m. were prospectively included and assigned to (1) control group (PEG-ELS 4L) PEG 4L and electrolytes; (2) group AscPEG-2L a combination of PEG and ascorbic acid 2L; and (3) group PiMg sodium picosulfate and magnesium citrate 500 mL plus 2L of clear fluids. Tolerability was evaluated with a questionnaire and the quality of bowel preparation with the Boston Bowel Preparation Scale.RESULTS:
A total of 292 participants were included 98 in the PEG-ELS 4L control group, 96 in the AscPEG-2L study group and 98 in the PiMg study group. Low-volume treatments were better tolerated than the standard solution (AscPEG-2L 94.8% and PiMg 93.9% vs PEG-ELS 4L 75.5%; p < 0.0001). The effectiveness of AscPEG-2L was superior to that of PEG-ELS 4L and PiMg (p = 0.011 and p = 0.032, respectively). Patient acceptance was higher for single-dose than for split-dose administration but efficacy was higher with the split dose than with other doses.CONCLUSIONS:
In early morning colonoscopies, ascPEG-2L appears to be the best option, especially when administered in a split-dose.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Polietilenglicoles
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Ácido Ascórbico
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Neoplasias Colorrectales
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Catárticos
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Colonoscopía
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Defecación
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Detección Precoz del Cáncer
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Screening_studies
Idioma:
En
Revista:
Gastroenterol Hepatol
Año:
2015
Tipo del documento:
Article
País de afiliación:
España