Expression of CD44 and CD35 during normal and myelodysplastic erythropoiesis.
Leuk Res
; 39(3): 361-70, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25582385
ABSTRACT
Erythroid dysplasia is a common feature of myelodysplastic syndromes (MDS). Currently available information about the immunophenotypic features of normal and dysplastic erythropoiesis is scarce and restricted to relatively few markers. Here we studied the expression of CD117, CD35 and CD44 throughout the normal (n=16) and dysplastic (n=48) bone marrow erythroid maturation. CD35 emerged as an early marker of CD34(+) erythroid-committed precursors, which is expressed before CD105 and remains positive thereafter. MDS patients (with and without morphologic dyserythropoiesis) displayed overall increased expression of CD44, associated with slight alterations on CD35 expression, suggesting that phenotypic alterations in MDS may precede morphologic dysplasia. In turn, MDS patients with anemia showed increased expression of CD117.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Médula Ósea
/
Síndromes Mielodisplásicos
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Biomarcadores de Tumor
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Células Precursoras Eritroides
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Receptores de Complemento 3b
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Receptores de Hialuranos
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Eritropoyesis
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Leuk Res
Año:
2015
Tipo del documento:
Article