The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.
Am J Med Genet A
; 167A(8): 1741-6, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25900621
ABSTRACT
"The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway Towards a Therapeutic Approach" was held at the Renaissance Orlando at SeaWorld Hotel (August 2-4, 2013). Seventy-one physicians and scientists attended the meeting, and parallel meetings were held by patient advocacy groups (CFC International, Costello Syndrome Family Network, NF Network and Noonan Syndrome Foundation). Parent and patient advocates opened the meeting with a panel discussion to set the stage regarding their hopes and expectations for therapeutic advances. In keeping with the theme on therapeutic development, the sessions followed a progression from description of the phenotype and definition of therapeutic endpoints, to definition of genomic changes, to identification of therapeutic targets in the RAS/MAPK pathway, to preclinical drug development and testing, to clinical trials. These proceedings will review the major points of discussion.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Proteínas ras
/
Sistema de Señalización de MAP Quinasas
/
Enfermedades Genéticas Congénitas
Límite:
Humans
Idioma:
En
Revista:
Am J Med Genet A
Asunto de la revista:
GENETICA MEDICA
Año:
2015
Tipo del documento:
Article