The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Cancer Invest
; 33(7): 267-75, 2015.
Article
en En
| MEDLINE
| ID: mdl-25950085
ABSTRACT
We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased. In ASPC-1 cancer cells, the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells. Moreover, the increased expression of miR-148a arrested the UTR methylation of p27, giving rise to an increased level of p27. Interestingly, it was shown that the DNMT1 inhibition enhanced the expression of miR-148a. In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Pancreáticas
/
MicroARNs
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ADN (Citosina-5-)-Metiltransferasas
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Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cancer Invest
Año:
2015
Tipo del documento:
Article
País de afiliación:
China