The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections.
Ecancermedicalscience
; 9: 534, 2015.
Article
en En
| MEDLINE
| ID: mdl-26015803
ABSTRACT
Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.
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Colección:
01-internacional
Idioma:
En
Revista:
Ecancermedicalscience
Año:
2015
Tipo del documento:
Article