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Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.
Ye, Zhao; Li, Zhiqiang; Wang, Yongfei; Mao, Ying; Shen, Ming; Zhang, Qilin; Li, Shiqi; Zhou, Liangfu; Shou, Xuefei; Chen, Jianhua; Song, Zhijian; Ma, Zengyi; Zhang, Zhaoyun; Li, Yiming; Ye, Hongying; Huang, Chuanxin; Wang, Tao; He, Wenqiang; Zhang, Yichao; Xie, Rong; Qiao, Nidan; Qiu, Huijia; Huang, Shan; Wang, Meng; Shen, Jiawei; Wen, Zujia; Li, Wenjin; Liu, Ke; Zhou, Juan; Wang, Lin; Ji, Jue; Wang, Yin; Chen, Hong; Cheng, Haixia; Shi, Zhifeng; Zhu, Yuqian; Geng, Daoying; Yao, Zhenwei; Tang, Weijun; Lu, Bin; Pan, Li; Zhang, Yi; Bao, Weimin; Wu, Jinsong; Zheng, Kang; Shi, Yongyong; Zhao, Yao.
Afiliación
  • Ye Z; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Li Z; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Wang Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Mao Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Shen M; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhang Q; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Li S; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhou L; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Shou X; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Chen J; 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Med
  • Song Z; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Ma Z; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhang Z; 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Li Y; 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Ye H; 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Huang C; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang T; Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • He W; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhang Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Xie R; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Qiao N; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Qiu H; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Huang S; Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Shen J; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Wen Z; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Li W; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Liu K; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Zhou J; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Wang L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Ji J; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
  • Wang Y; Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Chen H; Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Cheng H; Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Shi Z; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhu Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Geng D; Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Yao Z; Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Tang W; Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Lu B; 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Pan L; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zhang Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Bao W; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Wu J; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Zheng K; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
  • Shi Y; 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Med
  • Zhao Y; 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Nat Genet ; 47(7): 793-7, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26029870
ABSTRACT
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Hipofisarias / Cromosomas Humanos Par 10 / Cromosomas Humanos Par 13 / Adenoma / Polimorfismo de Nucleótido Simple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Hipofisarias / Cromosomas Humanos Par 10 / Cromosomas Humanos Par 13 / Adenoma / Polimorfismo de Nucleótido Simple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: China