Photoacoustic- and Magnetic Resonance-Guided Photothermal Therapy and Tumor Vasculature Visualization Using Theranostic Magnetic Gold Nanoshells.
J Biomed Nanotechnol
; 11(8): 1442-50, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26295144
ABSTRACT
Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here, we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration SPIO@AuNS. The novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Imagen por Resonancia Magnética
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Dextranos
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Diagnóstico por Imagen de Elasticidad
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Nanopartículas de Magnetita
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Hipertermia Inducida
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Neovascularización Patológica
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Biomed Nanotechnol
Año:
2015
Tipo del documento:
Article