Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors.
Curr Drug Targets
; 16(10): 1048-56, 2015.
Article
en En
| MEDLINE
| ID: mdl-26302794
ABSTRACT
Eph-ephrin system is emerging as a new potential target in several diseases including cancer, diabetes, neurodegenerative diseases and inflammation. In the last decade, several efforts have been made to develop small molecule antagonists of Eph receptors. Both natural and synthetic compounds were discovered with (poly) phenol and steroidal derivatives on one side and the α1 agonist doxazosin, 2,5-dimethylpyrrol- 1-yl-benzoic acids and amino acid conjugates of lithocholic acid on the other. In the present paper we critically present available data for these compounds and discuss their potential usefulness as pharmacological tools or as candidates for a lead-optimization program.
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Colección:
01-internacional
Asunto principal:
Preparaciones de Plantas
/
Receptores de la Familia Eph
/
Efrinas
/
Inhibidores de Proteínas Quinasas
/
Bibliotecas de Moléculas Pequeñas
/
Descubrimiento de Drogas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Drug Targets
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2015
Tipo del documento:
Article