Thyroid Transcription Factor-1 Expression in Adenocarcinomas of the Bile Duct.
Int J Surg Pathol
; 24(1): 24-8, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26316052
ABSTRACT
BACKGROUND:
The immunoreactivity of thyroid transcription factor-1 (TTF-1) is a very specific marker for lung and thyroid neoplasms; the expression of TTF-1 has also been demonstrated in extrapulmonary carcinomas. We examined the expression of TTF-1 in 15 intestinal-type adenocarcinomas of the extrahepatic bile duct. We then compared the expression to TTF-1 staining with other immunohistochemical markers including cytokeratin (CK) 7, CK20, caudal-type homeobox transcription factor 2 (CDX2), Napsin A, and MUC2. We additionally compared the clinicopathological prognostic factors with the TTF-1 expression status.RESULTS:
Nuclear TTF-1 staining was detected in 2 cases (13.3%), and Napsin A was positive in the same 2 cases (13.3%). All cases were positive for CK20, CDX2, and MUC2; 5 cases were positive for CK7. There was no correlation between TTF-1 expression and the clinicopathological characteristics.CONCLUSIONS:
To avoid potential pitfalls, TTF-1 should be interpreted in conjunction with the clinical setting, histology, and the results of markers such as CK7, CK20, Napsin A, and CDX2. This report is the first of TTF-1 positivity in adenocarcinomas from the extrahepatic biliary tract.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Factores de Transcripción
/
Neoplasias de los Conductos Biliares
/
Proteínas Nucleares
/
Adenocarcinoma
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Int J Surg Pathol
Asunto de la revista:
PATOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
México