Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.
Acta Pharmacol Sin
; 36(10): 1219-27, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26388155
ABSTRACT
Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Pharmacol Sin
Asunto de la revista:
FARMACOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China