Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition.
Tissue Antigens
; 86(6): 393-405, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26514448
ABSTRACT
T cell responses are generally regarded as specific for protein-derived peptide antigens. This is based on the molecular paradigm dictated by the T cell receptor (TCR) recognition of peptide-major histocompatibility complexs, which provides the molecular bases of the specificity and restriction of the T cell responses. An increasing number of findings in the last 20 years have challenged this paradigm, by showing the existence of T cells specific for lipid antigens presented by CD1 molecules. CD1-restricted T cells have been proven to be frequent components of the immune system and to recognize exogenous lipids, derived from pathogenic bacteria, as well as cell-endogenous self-lipids. This represents a young and exciting area of research in immunology with intriguing biological bases and a potential direct impact on human health.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Autoantígenos
/
Autotolerancia
/
Presentación de Antígeno
/
Antígenos CD1
/
Especificidad del Receptor de Antígeno de Linfocitos T
/
Lípidos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Tissue Antigens
Año:
2015
Tipo del documento:
Article
País de afiliación:
Italia