Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.

Sharma, Nilesh K; Kumar, Ashutosh; Kumari, Amrita; Tokar, Erik J; Waalkes, Michael P; Bortner, Carl D; Williams, Jason; Ehrenshaft, Marilyn; Mason, Ronald P; Sinha, Birandra K

Sharma, Nilesh K; Kumar, Ashutosh; Kumari, Amrita; Tokar, Erik J; Waalkes, Michael P; Bortner, Carl D; Williams, Jason; Ehrenshaft, Marilyn; Mason, Ronald P; Sinha, Birandra K.

Afiliación

Sharma NK; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Kumar A; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Kumari A; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Tokar EJ; National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Waalkes MP; National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Bortner CD; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Williams J; Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Ehrenshaft M; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Mason RP; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.
Sinha BK; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle, Park, Durham, North Carolina, United States of America.

PLoS One ; 10(11): e0141897, 2015.

Article en En | MEDLINE | ID: mdl-26540186

Asunto(s)

Neoplasias de la Mama/genética; Camptotecina/farmacología; ADN-Topoisomerasas de Tipo I/genética; Regulación hacia Abajo/genética; Resistencia a Antineoplásicos/genética; Óxido Nítrico/metabolismo; Neoplasias de la Mama/tratamiento farmacológico; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/genética; Regulación hacia Abajo/efectos de los fármacos; Resistencia a Antineoplásicos/efectos de los fármacos; Etopósido/farmacología; Células HT29; Humanos; Células MCF-7; Inhibidores de Topoisomerasa I/farmacología; Células Tumorales Cultivadas; Regulación hacia Arriba/efectos de los fármacos; Regulación hacia Arriba/genética

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Mama / Camptotecina / Regulación hacia Abajo / ADN-Topoisomerasas de Tipo I / Resistencia a Antineoplásicos / Óxido Nítrico Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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