Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction.
Cardiovasc Intervent Radiol
; 39(6): 916-9, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-26585991
ABSTRACT
PURPOSE:
We describe the design and preliminary characterization of a stent incorporating light-emitting diodes (LEDs) for photodynamic therapy (PDT) of malignant biliary obstruction.METHODS:
A prototype was constructed with red (640 nm) LEDs embedded in a 14.5 French polyurethane tube. The device was evaluated for optical power and subjected to physical and electrical tests. PDT-induced reactive oxygen species were imaged in a gel phantom.RESULTS:
The stent functioned at a 2.5-cm bend radius and illuminated for 6 months in saline. No stray currents were detected, and it was cool after 30 minutes of operation. Optical power of 5-15 mW is applicable to PDT. Imaging of a reactive oxygen indicator showed LED-stent activation of photosensitizer.CONCLUSIONS:
The results motivate biological testing and design optimization.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Fotoquimioterapia
/
Neoplasias de los Conductos Biliares
/
Stents
/
Colestasis
Límite:
Humans
Idioma:
En
Revista:
Cardiovasc Intervent Radiol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos