NF-Y activates genes of metabolic pathways altered in cancer cells.
Oncotarget
; 7(2): 1633-50, 2016 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-26646448
ABSTRACT
The trimeric transcription factor NF-Y binds to the CCAAT box, an element enriched in promoters of genes overexpressed in tumors. Previous studies on the NF-Y regulome identified the general term metabolism as significantly enriched. We dissect here in detail the targeting of metabolic genes by integrating analysis of NF-Y genomic binding and profilings after inactivation of NF-Y subunits in different cell types. NF-Y controls de novo biosynthetic pathways of lipids, teaming up with the master SREBPs regulators. It activates glycolytic genes, but, surprisingly, is neutral or represses mitochondrial respiratory genes. NF-Y targets the SOCG (Serine, One Carbon, Glycine) and Glutamine pathways, as well as genes involved in the biosynthesis of polyamines and purines. Specific cancer-driving nodes are generally under NF-Y control. Altogether, these data delineate a coherent strategy to promote expression of metabolic genes fuelling anaerobic energy production and other anabolic pathways commonly altered in cancer cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Perfilación de la Expresión Génica
/
Factor de Unión a CCAAT
/
Interferencia de ARN
/
Redes y Vías Metabólicas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Oncotarget
Año:
2016
Tipo del documento:
Article
País de afiliación:
Italia