Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

Zakaria, Z; Tivnan, A; Flanagan, L; Murray, D W; Salvucci, M; Stringer, B W; Day, B W; Boyd, A W; Kögel, D; Rehm, M; O'Brien, D F; Byrne, A T; Prehn, J H M

Zakaria, Z; Tivnan, A; Flanagan, L; Murray, D W; Salvucci, M; Stringer, B W; Day, B W; Boyd, A W; Kögel, D; Rehm, M; O'Brien, D F; Byrne, A T; Prehn, J H M.

Afiliación

Zakaria Z; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Tivnan A; National Centre for Neurosurgery, Beaumont Hospital, Dublin 9, Ireland.
Flanagan L; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Murray DW; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Salvucci M; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Stringer BW; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Day BW; Brain Cancer Research Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Boyd AW; Brain Cancer Research Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kögel D; Brain Cancer Research Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Rehm M; Experimental Neurosurgery, Neuroscience Center, Frankfurt University Hospital, Frankfurt am Main, Germany.
O'Brien DF; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Byrne AT; National Centre for Neurosurgery, Beaumont Hospital, Dublin 9, Ireland.
Prehn JH; Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Br J Cancer ; 114(2): 188-98, 2016 Jan 19.

Article en En | MEDLINE | ID: mdl-26657652

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Apoptosis/efectos de los fármacos; Neoplasias Encefálicas/patología; Dacarbazina/análogos & derivados; Dipéptidos/farmacología; Glioblastoma/patología; Indoles/farmacología; Proteínas Inhibidoras de la Apoptosis/antagonistas & inhibidores; Animales; Western Blotting; Caspasa 8/efectos de los fármacos; Caspasa 8/metabolismo; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Dacarbazina/farmacología; Resistencia a Antineoplásicos/efectos de los fármacos; Citometría de Flujo; Humanos; Técnicas In Vitro; Ratones; Ratones Endogámicos NOD; Ratones SCID; Microscopía de Contraste de Fase; Trasplante de Neoplasias; Temozolomida; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Encefálicas / Protocolos de Quimioterapia Combinada Antineoplásica / Apoptosis / Glioblastoma / Dacarbazina / Dipéptidos / Proteínas Inhibidoras de la Apoptosis / Indoles Límite: Animals / Humans Idioma: En Revista: Br J Cancer Año: 2016 Tipo del documento: Article País de afiliación: Irlanda

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