Jet injection of a monoclonal antibody: A preliminary study.
Annu Int Conf IEEE Eng Med Biol Soc
; 2015: 7336-40, 2015.
Article
en En
| MEDLINE
| ID: mdl-26737986
ABSTRACT
Monoclonal antibodies (mAbs) represent a major group of biotherapeutics. The high concentration and volume of drug administered together with a shift to administration via the subcutaneous route have generated interest in alternative delivery technologies. The feasibility of using a novel, highly controllable jet injection technology to deliver a mAb is presented. The effect of delivery parameters on protein structure were evaluated and compared with delivery using a conventional needle and syringe. Injection of mAb into a rat model showed that jet injection using the device resulted in more rapid absorption and longer duration of exposure.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Inyecciones a Chorro
/
Anticuerpos Monoclonales
Límite:
Animals
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Año:
2015
Tipo del documento:
Article