Local Control of Aldosterone Production and Primary Aldosteronism.
Trends Endocrinol Metab
; 27(3): 123-131, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26803728
ABSTRACT
Primary aldosteronism (PA) is caused by excessive production of aldosterone by the adrenal cortex and is determined by a benign aldosterone-producing adenoma (APA) in a significant proportion of cases. Local mechanisms, as opposed to circulatory ones, that control aldosterone production in the adrenal cortex are particularly relevant in the physiopathological setting and in the pathogenesis of PA. A breakthrough in our understanding of the pathogenetic mechanisms in APA has been the identification of somatic mutations in genes controlling membrane potential and intracellular calcium concentrations. However, recent data show that the processes of nodule formation and aldosterone hypersecretion can be dissociated in pathological adrenals and suggest a model envisaging different molecular events for the pathogenesis of APA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Regulación de la Expresión Génica
/
Corteza Suprarrenal
/
Aldosterona
/
Hiperaldosteronismo
/
Modelos Biológicos
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2016
Tipo del documento:
Article