Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities.

Kant, Rama; Kumar, Dharmendra; Agarwal, Drishti; Gupta, Rinkoo Devi; Tilak, Ragini; Awasthi, Satish Kumar; Agarwal, Alka

Kant, Rama; Kumar, Dharmendra; Agarwal, Drishti; Gupta, Rinkoo Devi; Tilak, Ragini; Awasthi, Satish Kumar; Agarwal, Alka.

Afiliación

Kant R; Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India.
Kumar D; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India.
Agarwal D; Faculty of Life Sciences and Biotechnology, South Asian University, Delhi 110021, India.
Gupta RD; Faculty of Life Sciences and Biotechnology, South Asian University, Delhi 110021, India.
Tilak R; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India.
Awasthi SK; Chemical Biology Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India. Electronic address: skawasthi@chemistry.du.ac.in.
Agarwal A; Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, UP, India. Electronic address: agarwal.dralka@gmail.com.

Eur J Med Chem ; 113: 34-49, 2016 May 04.

Article en En | MEDLINE | ID: mdl-26922227

Asunto(s)

Antibacterianos/farmacología; Antifúngicos/farmacología; Antimaláricos/farmacología; Bacterias/efectos de los fármacos; Hongos/efectos de los fármacos; Plasmodium falciparum/efectos de los fármacos; Triazoles/farmacología; Antibacterianos/síntesis química; Antibacterianos/química; Antifúngicos/síntesis química; Antifúngicos/química; Antimaláricos/síntesis química; Antimaláricos/química; Línea Celular Tumoral; Chalcona/química; Chalcona/farmacología; Relación Dosis-Respuesta a Droga; Flavonas/química; Flavonas/farmacología; Humanos; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Pruebas de Sensibilidad Parasitaria; Relación Estructura-Actividad; Triazoles/síntesis química; Triazoles/química

Palabras clave

1,2,3-Triazole; Antibacterial activity; Antifungal activity; Antiplasmodial activity; Chalcone; Cytotoxicity

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Texto completo: 1 Colección: 01-internacional Asunto principal: Plasmodium falciparum / Bacterias / Triazoles / Hongos / Antibacterianos / Antifúngicos / Antimaláricos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2016 Tipo del documento: Article País de afiliación: India

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