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The role of adiponectin in obesity-associated female-specific carcinogenesis.
Nagaraju, Ganji Purnachandra; Rajitha, Balney; Aliya, Sheik; Kotipatruni, Rama P; Madanraj, Appiya Santharam; Hammond, Anthea; Park, Dongkyoo; Chigurupati, Srinivasulu; Alam, Afroz; Pattnaik, Subasini.
Afiliación
  • Nagaraju GP; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: pganji@emory.edu.
  • Rajitha B; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: rajitha.balney@wellstar.org.
  • Aliya S; Department of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh 500085, India. Electronic address: biotechaliya@gmail.com.
  • Kotipatruni RP; Department of Radiation Oncology, Cancer Biology Division, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, United States. Electronic address: rkotipatruni@uchicago.edu.
  • Madanraj AS; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom. Electronic address: madanraj.appiah@gmail.com.
  • Hammond A; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: alhammo@emory.edu.
  • Park D; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: dpark33@emory.edu.
  • Chigurupati S; Office of Regulatory Science, Food and Drug Administration, Rockville, MD 20857, United States. Electronic address: srinivasulu.chigurupati@fda.hhs.gov.
  • Alam A; Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: aafroj@banasthali.in.
  • Pattnaik S; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: sp.zool@buodisha.edu.in.
Cytokine Growth Factor Rev ; 31: 37-48, 2016 10.
Article en En | MEDLINE | ID: mdl-27079372
ABSTRACT
Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Adiponectina / Carcinogénesis / Obesidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cytokine Growth Factor Rev Asunto de la revista: ALERGIA E IMUNOLOGIA / BIOQUIMICA Año: 2016 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Asunto principal: Adiponectina / Carcinogénesis / Obesidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cytokine Growth Factor Rev Asunto de la revista: ALERGIA E IMUNOLOGIA / BIOQUIMICA Año: 2016 Tipo del documento: Article