Polyamine signal through gap junctions: A key regulator of proliferation and gap-junction organization in mammalian tissues?
Bioessays
; 38(6): 498-507, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-27125471
ABSTRACT
We propose that interaction rules derived from polyamine exchange in connected cells may explain the spatio-temporal organization of gap junctions observed during tissue regeneration and tumorigenesis. We also hypothesize that polyamine exchange can be considered as signal that allows cells to sense the proliferation status of their neighbors. Polyamines (putrescine, spermidine, and spermine) are indeed small aliphatic polycations that serve as fuels to sustain elevated proliferation rates of the order observed in cancer cells. Based on recent reports, we consider here that polyamines can be exchanged through gap junction channels between mammalian cells. Such intercellular exchange of polyamines has critical consequences on the local control of growth. In line with this hypothesis, the complex protein network that keeps polyamine levels finely tuned in mammalian cells can translate polyamine efflux or influx into integrated signals controlling transcription, translation, and cell communications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Poliaminas
/
Transducción de Señal
/
Uniones Comunicantes
/
Proliferación Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioessays
Asunto de la revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia