Store-operated CRAC channel inhibitors: opportunities and challenges.
Future Med Chem
; 8(7): 817-32, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-27149324
ABSTRACT
Aberrant Ca(2+) release-activated Ca(2+) (CRAC) channel activity has been implicated in a number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular diseases and cancer, thus placing CRAC channels among the important targets for the treatment of these disorders. We briefly summarize herein the molecular basis and activation mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of CRAC channels with respect to their biological activity, mechanisms of action and selectivity over other types of Ca(2+) channel in different types of cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Canales de Calcio Activados por la Liberación de Calcio
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2016
Tipo del documento:
Article
País de afiliación:
China