Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs.
J Vet Intern Med
; 30(4): 1197-203, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-27160025
ABSTRACT
BACKGROUND:
Histiocytic sarcoma (HS) is a rare but aggressive malignancy in humans that is poorly responsive to existing treatments. Although rare in most breeds of dogs, HS is common in Bernese mountain dogs (BMDs).OBJECTIVE:
Determine risk factors associated with development of HS in BMD. ANIMALS A total of 216 BMD were registered with the Berner-Garde Foundation.METHODS:
An internet-based cross-sectional survey was used to collect information from owners of BMD diagnosed with HS and owners of disease-free littermates of dogs with HS. Mixed-effects logistic regression (MELR) and conditional logistic regression (CLR) were used in parallel to examine associations between potential risk factors and the occurrence of HS.RESULTS:
When controlling for litter as a marker of relatedness, dogs diagnosed with orthopedic conditions were found to be more likely to develop HS (MELR, OR 2.5, 95% CI 1.5, 5.2; CLR, OR 2.81, 95% CI 1.1, 7.3), whereas dogs receiving prescription anti-inflammatory medications were found to be at considerably lower risk of developing HS (MELR, OR 0.42, 95% CI 0.2, 0.8; CLR, OR 0.32, 95% CI 0.1, 0.8). CONCLUSIONS AND CLINICAL IMPORTANCE These results suggest inflammation may be a modifiable risk factor for the development of HS in BMD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Enfermedades de los Perros
/
Sarcoma Histiocítico
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Vet Intern Med
Asunto de la revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Colombia