Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.

Nguyen, Tuyet Thi; Quan, Xianglan; Xu, Shanhua; Das, Ranjan; Cha, Seung-Kuy; Kong, In Deok; Shong, Minho; Wollheim, Claes B; Park, Kyu-Sang

Nguyen, Tuyet Thi; Quan, Xianglan; Xu, Shanhua; Das, Ranjan; Cha, Seung-Kuy; Kong, In Deok; Shong, Minho; Wollheim, Claes B; Park, Kyu-Sang.

Afiliación

Nguyen TT; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Quan X; Department of Physiology, Tan-Tao University College of Medicine, Long An, Vietnam.
Xu S; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Das R; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Cha SK; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Kong ID; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Shong M; Mitohormesis Translational Research Center, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Wollheim CB; Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
Park KS; Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea; and.

FASEB J ; 30(12): 3979-3988, 2016 12.

Article en En | MEDLINE | ID: mdl-27565711

Asunto(s)

Transporte Biológico/efectos de los fármacos; Transporte Iónico/genética; Mitocondrias/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; Fosfatos/farmacología; Proteínas Cotransportadoras de Sodio-Fosfato de Tipo III/metabolismo; Animales; Membrana Celular/metabolismo; Células Cultivadas; Homeostasis/efectos de los fármacos; Insulina/metabolismo; Secreción de Insulina; Células Secretoras de Insulina/efectos de los fármacos; Células Secretoras de Insulina/metabolismo; Mitocondrias/metabolismo; Ratas

Palabras clave

endoplasmic reticulum stress; inorganic phosphate; mitochondrial permeability transition; pancreatic ß cells; superoxide

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Colección: 01-internacional Asunto principal: Fosfatos / Transporte Biológico / Transporte Iónico / Estrés Oxidativo / Proteínas Cotransportadoras de Sodio-Fosfato de Tipo III / Mitocondrias Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2016 Tipo del documento: Article

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