Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide.
Dokl Biochem Biophys
; 469(1): 239-43, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-27599502
ABSTRACT
The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1ß mRNA in SK-N-SH cells induced by LPS.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Proteínas Recombinantes
/
Lipopolisacáridos
/
Proteínas HSP70 de Choque Térmico
/
Factores Inmunológicos
/
Neuroblastoma
Límite:
Humans
Idioma:
En
Revista:
Dokl Biochem Biophys
Asunto de la revista:
BIOFISICA
/
BIOQUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Rusia