Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases.

Tokarsky, E John; Gadkari, Varun V; Zahurancik, Walter J; Malik, Chanchal K; Basu, Ashis K; Suo, Zucai

Tokarsky, E John; Gadkari, Varun V; Zahurancik, Walter J; Malik, Chanchal K; Basu, Ashis K; Suo, Zucai.

Afiliación

Tokarsky EJ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biophysics Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: tokarsky.8@osu.edu.
Gadkari VV; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gadkari.3@osu.edu.
Zahurancik WJ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: zahurancik.2@osu.edu.
Malik CK; Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA. Electronic address: malikchanchal@gmail.com.
Basu AK; Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA. Electronic address: ashis.basu@uconn.edu.
Suo Z; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: suo.3@osu.

DNA Repair (Amst) ; 46: 20-28, 2016 10.

Article en En | MEDLINE | ID: mdl-27612622

Asunto(s)

Benzo(a)Antracenos/farmacología; Daño del ADN; Replicación del ADN; ADN Polimerasa Dirigida por ADN/genética; ADN Polimerasa Dirigida por ADN/metabolismo; Mutágenos/farmacología; Benzo(a)Antracenos/metabolismo; ADN/química; ADN/metabolismo; Aductos de ADN/biosíntesis; Reparación del ADN; Guanina/análogos & derivados; Células HEK293; Humanos; Cinética; Mutágenos/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Nucleotidiltransferasas/genética; Nucleotidiltransferasas/metabolismo; ADN Polimerasa iota

Palabras clave

3-Nitrobenzanthrone; DNA repair; DNA replication; Human DNA polymerase eta; Translesion synthesis

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Texto completo: 1 Colección: 01-internacional Asunto principal: Benzo(a)Antracenos / Daño del ADN / ADN Polimerasa Dirigida por ADN / Replicación del ADN / Mutágenos Límite: Humans Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2016 Tipo del documento: Article

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