Protection of endothelial cells against Ang II-induced impairment: Involvement of both PPARα and PPARγ via PI3K/Akt pathway.
Clin Exp Hypertens
; 38(7): 571-577, 2016.
Article
en En
| MEDLINE
| ID: mdl-27650941
ABSTRACT
The aim of our study is to explore the involvement of PPARα and PPARγ in Ang II-induced endothelial injury. We found that Ang II significantly elevated the oxidative stress in HUVECs, causing apoptosis and cellular impairment in a time-dependent pattern. Activation of either PPARα by docosahexaenoic acid (DHA) or PPARγ by rosiglitazone protected the endothelial cells. Interestingly, a more significant effect was observed when DHA and rosiglitazone were administrated together. Moreover, we found that this protection was mediated through the PI3K/Akt pathway. Our study may help to understand the mechanism of endothelial dysfunction, contributing to the treatment of hypertension and other endothelial-related diseases.
Palabras clave
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Colección:
01-internacional
Asunto principal:
Angiotensina II
/
Ácidos Docosahexaenoicos
/
Estrés Oxidativo
/
Células Endoteliales
/
Tiazolidinedionas
/
PPAR alfa
/
PPAR gamma
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Hypertens
Año:
2016
Tipo del documento:
Article
País de afiliación:
China