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Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.
Bhattarai, Deepak; Jung, Joo Hyun; Han, Seunghyeon; Lee, Hankyu; Oh, Soo Jin; Ko, Hyuk Wan; Lee, Kyeong.
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  • Bhattarai D; BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea.
  • Jung JH; College of Pharmacy, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea.
  • Han S; BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea.
  • Lee H; College of Pharmacy, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea.
  • Oh SJ; Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 363-883, Republic of Korea.
  • Ko HW; College of Pharmacy, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea. Electronic address: kohw@dongguk.edu.
  • Lee K; BK21Plus R-FIND Team, College of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, 410-820, Republic of Korea. Electronic address: Kaylee@dongguk.edu.
Eur J Med Chem ; 125: 1036-1050, 2017 Jan 05.
Article en En | MEDLINE | ID: mdl-27810591
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Texto completo: 1 Colección: 01-internacional Asunto principal: Transducción de Señal / Quinazolinonas / Proteínas Hedgehog / Isoindoles Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Transducción de Señal / Quinazolinonas / Proteínas Hedgehog / Isoindoles Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article