Gene Therapy of Salivary Diseases.
Methods Mol Biol
; 1537: 107-123, 2017.
Article
en En
| MEDLINE
| ID: mdl-27924590
ABSTRACT
For many years, our research group worked to develop gene transfer approaches for salivary gland disorders that lacked effective conventional therapy. The purpose of this chapter is to describe and update key methods used in this process. As described in our original chapter from the 2010 volume, we focus on one clinical condition, irradiation-induced salivary hypofunction, and address the choice of transgene and vector to be used, the construction of recombinant viral vectors, how vector delivery is accomplished, and methods for assessing vector function in vitro and in an appropriate animal model.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Enfermedades de las Glándulas Salivales
/
Terapia Genética
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos