Exome and genome sequencing of nasopharynx cancer identifies NF-&#954;B pathway activating mutations.

Li, Yvonne Y; Chung, Grace T Y; Lui, Vivian W Y; To, Ka-Fai; Ma, Brigette B Y; Chow, Chit; Woo, John K S; Yip, Kevin Y; Seo, Jeongsun; Hui, Edwin P; Mak, Michael K F; Rusan, Maria; Chau, Nicole G; Or, Yvonne Y Y; Law, Marcus H N; Law, Peggy P Y; Liu, Zoey W Y; Ngan, Hoi-Lam; Hau, Pok-Man; Verhoeft, Krista R; Poon, Peony H Y; Yoo, Seong-Keun; Shin, Jong-Yeon; Lee, Sau-Dan; Lun, Samantha W M; Jia, Lin; Chan, Anthony W H; Chan, Jason Y K; Lai, Paul B S; Fung, Choi-Yi; Hung, Suet-Ting; Wang, Lin; Chang, Ann Margaret V; Chiosea, Simion I; Hedberg, Matthew L; Tsao, Sai-Wah; van Hasselt, Andrew C; Chan, Anthony T C; Grandis, Jennifer R; Hammerman, Peter S; Lo, Kwok-Wai

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Li, Yvonne Y; Chung, Grace T Y; Lui, Vivian W Y; To, Ka-Fai; Ma, Brigette B Y; Chow, Chit; Woo, John K S; Yip, Kevin Y; Seo, Jeongsun; Hui, Edwin P; Mak, Michael K F; Rusan, Maria; Chau, Nicole G; Or, Yvonne Y Y; Law, Marcus H N; Law, Peggy P Y; Liu, Zoey W Y; Ngan, Hoi-Lam; Hau, Pok-Man; Verhoeft, Krista R; Poon, Peony H Y; Yoo, Seong-Keun; Shin, Jong-Yeon; Lee, Sau-Dan; Lun, Samantha W M; Jia, Lin; Chan, Anthony W H; Chan, Jason Y K; Lai, Paul B S; Fung, Choi-Yi; Hung, Suet-Ting; Wang, Lin; Chang, Ann Margaret V; Chiosea, Simion I; Hedberg, Matthew L; Tsao, Sai-Wah; van Hasselt, Andrew C; Chan, Anthony T C; Grandis, Jennifer R; Hammerman, Peter S; Lo, Kwok-Wai.

Afiliación

Li YY; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Chung GT; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Lui VW; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
To KF; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ma BB; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Chow C; State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Woo JK; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Yip KY; Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Seo J; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Hui EP; Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 10-799, Republic of Korea.
Mak MK; State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Rusan M; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Chau NG; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Or YY; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Law MH; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Law PP; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Liu ZW; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Ngan HL; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Hau PM; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Verhoeft KR; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Poon PH; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yoo SK; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Shin JY; Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 10-799, Republic of Korea.
Lee SD; Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 10-799, Republic of Korea.
Lun SW; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
Jia L; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Chan AW; School of Biomedical Sciences and Center for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chan JY; Department of Anatomical &Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
Lai PB; Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Fung CY; Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Hung ST; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Wang L; Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chang AM; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA.
Chiosea SI; Institute of Pathology, St. Luke's Medical Center, Quezon City 1112, Philippines.
Hedberg ML; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA.
Tsao SW; Medical Scientist Training Program, University of Pittsburgh-Carnegie Mellon University, Pittsburgh, Pennsylvania 15261, USA.
van Hasselt AC; School of Biomedical Sciences and Center for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chan AT; Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Grandis JR; State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Hammerman PS; Department of Otolaryngology, University of California San Francisco, San Francisco, California 94113, USA.
Lo KW; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

Nat Commun ; 8: 14121, 2017 01 18.

Article en En | MEDLINE | ID: mdl-28098136

Asunto(s)

Carcinoma/genética; Infecciones por Virus de Epstein-Barr/genética; Exoma; Mutación; FN-kappa B/metabolismo; Neoplasias Nasofaríngeas/genética; Transducción de Señal; Carcinoma/metabolismo; Carcinoma/fisiopatología; Proliferación Celular; Enzima Desubiquitinante CYLD/genética; Enzima Desubiquitinante CYLD/metabolismo; Infecciones por Virus de Epstein-Barr/metabolismo; Infecciones por Virus de Epstein-Barr/fisiopatología; Infecciones por Virus de Epstein-Barr/virología; Genoma Humano; Herpesvirus Humano 4/genética; Herpesvirus Humano 4/metabolismo; Humanos; Inhibidor NF-kappaB alfa/genética; Inhibidor NF-kappaB alfa/metabolismo; FN-kappa B/genética; Carcinoma Nasofaríngeo; Neoplasias Nasofaríngeas/metabolismo; Neoplasias Nasofaríngeas/fisiopatología; Factor 3 Asociado a Receptor de TNF/genética; Factor 3 Asociado a Receptor de TNF/metabolismo; Proteínas de la Matriz Viral/genética; Proteínas de la Matriz Viral/metabolismo; Secuenciación Completa del Genoma

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Texto completo: 1 Colección: 01-internacional Asunto principal: Carcinoma / Transducción de Señal / Neoplasias Nasofaríngeas / FN-kappa B / Infecciones por Virus de Epstein-Barr / Exoma / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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