Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease.
J Vet Cardiol
; 19(2): 124-131, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-28111138
ABSTRACT
INTRODUCTION:
To determine the biologic variability of N-terminal pro-brain natriuretic peptide (NTproBNP) in healthy dogs and dogs with various stages of myxomatous mitral valve disease (MMVD). ANIMALS Thirty-eight privately owned dogs 28 with MMVD and 10 healthy controls. MATERIALS ANDMETHODS:
Prospective clinical study with comprehensive evaluation used to group dogs as healthy or into three stages of MMVD based on current guidelines. NTproBNP was measured hourly, daily, and weekly. For each group, analytical (CVA), within-subject (CVI), and between-subject (CVG) coefficients of variability were calculated in addition to percent critical change value (CCV) and index of individuality (IoI).RESULTS:
For healthy dogs, calculated NTproBNP values were CVA = 4.2%; CVI = 25.2%; CVG = 49.3%; IoI = 0.52, and CCV = 70.8%. For dogs with MMVD, calculated NTproBNP values were CVA = 6.2%; CVI = 20.0%; CVG = 61.3%; IoI = 0.34, and CCV = 58.2%.CONCLUSIONS:
Biologic variability affects NTproBNP concentrations in healthy dogs and dogs with MMVD. Monitoring serial individual changes in NTproBNP may be clinically relevant in addition to using population-based reference ranges to determine changes in disease status.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Fragmentos de Péptidos
/
Biomarcadores
/
Péptido Natriurético Encefálico
/
Enfermedades de los Perros
/
Perros
/
Insuficiencia de la Válvula Mitral
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Cardiol
Asunto de la revista:
CARDIOLOGIA
/
MEDICINA VETERINARIA
Año:
2017
Tipo del documento:
Article