Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia.
Cold Spring Harb Perspect Med
; 7(11)2017 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-28242784
ABSTRACT
Recent studies have shown the importance of chromatin-modifying complexes in the maintenance of developmental gene expression and human disease. The mixed lineage leukemia gene (MLL1) encodes a chromatin-modifying protein and was discovered as a result of the cloning of translocations involved in human leukemias. MLL1 is a histone lysine 4 (H3K4) methyltransferase that supports transcription of genes that are important for normal development including homeotic (Hox) genes. MLL1 rearrangements result in expression of fusion proteins without H3K4 methylation activity but may gain the ability to recruit other chromatin-associated complexes such as the H3K79 methyltransferase DOT1L and the super elongation complex. Therefore, chromosomal translocations involving MLL1 appear to directly perturb the regulation of multiple chromatin-associated complexes to allow inappropriate expression of developmentally regulated genes and thus drive leukemia development.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Cromatina
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Leucemia
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N-Metiltransferasa de Histona-Lisina
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Proteína de la Leucemia Mieloide-Linfoide
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Año:
2017
Tipo del documento:
Article