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Pre-metastatic niches: organ-specific homes for metastases.
Peinado, Héctor; Zhang, Haiying; Matei, Irina R; Costa-Silva, Bruno; Hoshino, Ayuko; Rodrigues, Goncalo; Psaila, Bethan; Kaplan, Rosandra N; Bromberg, Jacqueline F; Kang, Yibin; Bissell, Mina J; Cox, Thomas R; Giaccia, Amato J; Erler, Janine T; Hiratsuka, Sachie; Ghajar, Cyrus M; Lyden, David.
Afiliación
  • Peinado H; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Zhang H; Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
  • Matei IR; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Costa-Silva B; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Hoshino A; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Rodrigues G; Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, Avenida Brasília, Doca de Pedrouços, 1400-038 Lisbon, Portugal.
  • Psaila B; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Kaplan RN; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
  • Bromberg JF; Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal.
  • Kang Y; Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0HS, UK.
  • Bissell MJ; Center for Cancer Research, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10-Hatfield CRC, Room 1-3940, Bethesda, Maryland 20892, USA.
  • Cox TR; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
  • Giaccia AJ; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
  • Erler JT; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
  • Hiratsuka S; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
  • Ghajar CM; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia.
  • Lyden D; Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
Nat Rev Cancer ; 17(5): 302-317, 2017 05.
Article en En | MEDLINE | ID: mdl-28303905
ABSTRACT
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Metástasis de la Neoplasia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Rev Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Metástasis de la Neoplasia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Rev Cancer Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos