The cardiovascular functions of salusin-ß mediated by muscarinic receptors, glutamate receptors or L-type calcium channels within the rostral ventrolateral medulla of rats.
Microsc Res Tech
; 80(7): 812-819, 2017 Jul.
Article
en En
| MEDLINE
| ID: mdl-28371124
ABSTRACT
Salusin-α and salusin-ß are newly identified bioactive peptides of 28 and 20 amino acids, respectively, that were initially predicted using in silico analyses and are widely distributed in the endocrine system, hematopoietic system, and central nervous system. The goal of our study was to investigate the cardiovascular effect of salusin-ß microinjections into the rostral ventrolateral medulla (RVLM) in anesthetized rats and study their mechanism of action. Microinjection of the artificial cerebrospinal fluid (aCSF) into the RVLM did not affect the blood pressure (BP) or heart rate (HR) in anesthetized rats. Topical application of salusin-ß into the RVLM produced a dose-dependently increase of BP in anesthetized rats. Microinjection of higher dose salusin-ß produced significant tachycardia. Prior application of the L-NAME into the RVLM of rats did not alter the hypertension and tachycardia induced by intra-RVLM salusin-ß. Notable, the cardiovascular functions elicited by intra-RVLM salusin-ß were significantly decreased by pretreatment with Nic, KYN and atropine. In conclusion, the present study shows that the hypertension and tachycardia induced by intra-RVLM salusin-ß might be partly mediated, at least in our opinion, by muscarinic receptors, glutamate receptors or L-type calcium channels.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Bulbo Raquídeo
/
Fenómenos Fisiológicos Cardiovasculares
/
Receptores Muscarínicos
/
Receptores de Glutamato
/
Canales de Calcio Tipo L
/
Péptidos y Proteínas de Señalización Intercelular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Microsc Res Tech
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2017
Tipo del documento:
Article
País de afiliación:
China