Structured models of cell migration incorporating molecular binding processes.
J Math Biol
; 75(6-7): 1517-1561, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28405746
ABSTRACT
The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Movimiento Celular
/
Modelos Biológicos
Límite:
Humans
Idioma:
En
Revista:
J Math Biol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Alemania