Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways.

Edueng, Khadijah; Mahlin, Denny; Larsson, Per; Bergström, Christel A S

Edueng, Khadijah; Mahlin, Denny; Larsson, Per; Bergström, Christel A S.

Afiliación

Edueng K; Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O Box 580, SE-75123 Uppsala, Sweden; Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Istana, 25200 Bandar Indera Mahkota, Kuantan, Pahang, Malaysia. Electronic address: khadijah.edueng@farmaci.uu.se.
Mahlin D; Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O Box 580, SE-75123 Uppsala, Sweden. Electronic address: denny.mahlin@farmaci.uu.se.
Larsson P; Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O Box 580, SE-75123 Uppsala, Sweden. Electronic address: per.larsson@farmaci.uu.se.
Bergström CAS; Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O Box 580, SE-75123 Uppsala, Sweden. Electronic address: christel.bergstrom@farmaci.uu.se.

J Control Release ; 256: 193-202, 2017 06 28.

Article en En | MEDLINE | ID: mdl-28412224

Asunto(s)

Glipizida/química; Gliburida/química; Indapamida/química; Metolazona/química; Rastreo Diferencial de Calorimetría; Cristalización; Composición de Medicamentos; Liberación de Fármacos; Estabilidad de Medicamentos; Enlace de Hidrógeno; Derivados de la Hipromelosa/química; Simulación de Dinámica Molecular; Povidona/química; Espectrometría Raman

Palabras clave

Amorphous; Crystallization; Dissolution; Polymer; Solid-state; Stabilization; Supersaturation

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Texto completo: 1 Colección: 01-internacional Asunto principal: Gliburida / Glipizida / Indapamida / Metolazona Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article

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