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Good for the lung but bad for the liver? Garlic-induced hepatotoxicity following liver transplantation.
Shaikh, S A; Tischer, S; Choi, E K; Fontana, R J.
Afiliación
  • Shaikh SA; Department of Pharmacy Services and Clinical Sciences, Michigan Medicine, Ann Arbor, MI, USA.
  • Tischer S; Department of Pharmacy Services and Clinical Sciences, Michigan Medicine, Ann Arbor, MI, USA.
  • Choi EK; Department of Pathology, Michigan Medicine, Ann Arbor, MI, USA.
  • Fontana RJ; Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
J Clin Pharm Ther ; 42(5): 646-648, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28543822
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVE:

Limited data exist surrounding the metabolism and safety of garlic supplements. CASE DESCRIPTION A patient with a history of hepatopulmonary syndrome (HPS) and orthotopic liver transplantation was admitted to our surgery transplant service with severe hypoxaemia. The patient was started on high-dose Garlicin Cardio® (Allium sativum) for HPS and soon after had elevated liver function tests. Garlicin Cardio® was discontinued and liver enzymes normalized. A liver biopsy revealed mild periportal cholestatic reaction suggesting potential drug-induced aetiology. WHAT IS NEW AND

CONCLUSION:

This is the first description of liver injury secondary to garlic supplementation. Therefore, this garlic supplement should be listed as a potential cause of acute drug-induced liver injury.
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Palabras clave

Texto completo: 1 Colección: 01-internacional Asunto principal: Trasplante de Hígado / Suplementos Dietéticos / Enfermedad Hepática Inducida por Sustancias y Drogas / Ajo Límite: Adult / Humans / Male Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Asunto principal: Trasplante de Hígado / Suplementos Dietéticos / Enfermedad Hepática Inducida por Sustancias y Drogas / Ajo Límite: Adult / Humans / Male Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos