Good for the lung but bad for the liver? Garlic-induced hepatotoxicity following liver transplantation.
J Clin Pharm Ther
; 42(5): 646-648, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28543822
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Limited data exist surrounding the metabolism and safety of garlic supplements. CASE DESCRIPTION A patient with a history of hepatopulmonary syndrome (HPS) and orthotopic liver transplantation was admitted to our surgery transplant service with severe hypoxaemia. The patient was started on high-dose Garlicin Cardio® (Allium sativum) for HPS and soon after had elevated liver function tests. Garlicin Cardio® was discontinued and liver enzymes normalized. A liver biopsy revealed mild periportal cholestatic reaction suggesting potential drug-induced aetiology. WHAT IS NEW ANDCONCLUSION:
This is the first description of liver injury secondary to garlic supplementation. Therefore, this garlic supplement should be listed as a potential cause of acute drug-induced liver injury.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Trasplante de Hígado
/
Suplementos Dietéticos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Ajo
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos