TRIF-dependent Toll-like receptor signaling suppresses <i>Scd1</i> transcription in hepatocytes and prevents diet-induced hepatic steatosis.

Chen, Jing; Li, Jin; Yiu, Jensen H C; Lam, Jenny K W; Wong, Chi-Ming; Dorweiler, Bernhard; Xu, Aimin; Woo, Connie W

TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis.

Chen, Jing; Li, Jin; Yiu, Jensen H C; Lam, Jenny K W; Wong, Chi-Ming; Dorweiler, Bernhard; Xu, Aimin; Woo, Connie W.

Afiliación

Chen J; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
Li J; Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
Yiu JHC; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
Lam JKW; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
Wong CM; Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Dorweiler B; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
Xu A; Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
Woo CW; Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.

Sci Signal ; 10(491)2017 Aug 08.

Article en En | MEDLINE | ID: mdl-28790196

Asunto(s)

Proteínas Adaptadoras del Transporte Vesicular/metabolismo; Hígado Graso/genética; Hepatocitos/metabolismo; Estearoil-CoA Desaturasa/genética; Receptores Toll-Like/metabolismo; Proteínas Adaptadoras del Transporte Vesicular/genética; Animales; Dieta Alta en Grasa/efectos adversos; Hígado Graso/metabolismo; Células HEK293; Humanos; Inflamación/metabolismo; Factor 3 Regulador del Interferón/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Mutantes; Ácido Palmítico/metabolismo; Poli C/metabolismo; Cultivo Primario de Células

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Texto completo: 1 Colección: 01-internacional Asunto principal: Estearoil-CoA Desaturasa / Hepatocitos / Proteínas Adaptadoras del Transporte Vesicular / Receptores Toll-Like / Hígado Graso Límite: Animals / Humans / Male Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China

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