Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model.

Aryanpour, Roya; Pasbakhsh, Parichehr; Zibara, Kazem; Namjoo, Zeinab; Beigi Boroujeni, Fatemeh; Shahbeigi, Saeed; Kashani, Iraj Ragerdi; Beyer, Cordian; Zendehdel, Adib

Aryanpour, Roya; Pasbakhsh, Parichehr; Zibara, Kazem; Namjoo, Zeinab; Beigi Boroujeni, Fatemeh; Shahbeigi, Saeed; Kashani, Iraj Ragerdi; Beyer, Cordian; Zendehdel, Adib.

Afiliación

Aryanpour R; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Pasbakhsh P; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zibara K; ER045, Laboratory of Stem Cells, DSST, Biology Department, Faculty of Sciences, Lebanese University, Beirut, Lebanon.
Namjoo Z; Department of Anatomy, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Beigi Boroujeni F; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Shahbeigi S; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Kashani IR; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: ragerdi@tums.ac.ir.
Beyer C; Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany.
Zendehdel A; Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany; Giulan Neuroscience Research Center, Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Int Immunopharmacol ; 51: 131-139, 2017 Oct.

Article en En | MEDLINE | ID: mdl-28830026

Asunto(s)

Encéfalo/patología; Enfermedades Desmielinizantes/tratamiento farmacológico; Microglía/fisiología; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Progesterona/uso terapéutico; Animales; Diferenciación Celular/efectos de los fármacos; Células Cultivadas; Cuprizona/toxicidad; Citocinas/metabolismo; Modelos Animales de Enfermedad; Femenino; Humanos; Inflamasomas/metabolismo; Ratones; Ratones Endogámicos C57BL; Microglía/efectos de los fármacos; Fenotipo; Células TH1/inmunología; Balance Th1 - Th2/efectos de los fármacos; Células Th2/inmunología

Palabras clave

Cuprizone; Demyelination; Microglia; Multiple sclerosis; NLRP3; Progesterone

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Texto completo: 1 Colección: 01-internacional Asunto principal: Progesterona / Encéfalo / Enfermedades Desmielinizantes / Microglía / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Animals / Female / Humans Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Irán

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